Rich in cultural heritage, Hissor traces its history back 3500 years to the ancient town of Hissor, where archaeological findings indicate human habitation dating back 40 thousand years. The Hissor Historical and Cultural Reserve, established in the late 20th century, showcases archaeological and architectural monuments spanning various eras across its 86-hectare open-air museum.

One of the most renowned historical landmarks in Central Asia, the Hissor Fortress stands as a testament to the region's ancient past, having been constructed 2500 years ago. Originally serving as the residence of the Emir of Bukhara, the fortress features a main gate constructed in the 16th century, alongside remnants of its thick fortress walls, terraces, and a large garden. Adjacent to the fortress stand two towering plane trees, estimated to be between 500 to 700 years old.

Other notable attractions within the Hissor Historical and Cultural Reserve include the old and new Madrasas, the Caravan Saray "Hishtin," and the Makhdumi-Azam Mausoleum, each offering insights into the city's rich architectural and religious heritage. The Sangin Mosque, also known as the Stone Mosque, further adds to Hissor's architectural diversity, with its construction spanning the 12th to 16th centuries. Together, these historical landmarks paint a vivid picture of Hissor's illustrious past and cultural significance in the region.